SCS in Small Animals with SCI

SCS in Small Animals with SCI


Role of the Sensory Input

  • Lavrov et al., 2006 Plasticity of spinal cord reflexes after a complete transection in adult rats: relationship to stepping ability
  • Lavrov et al., 2008 Epidural stimulation induced modulation of spinal locomotor networks in adult spinal rats

Role of the Sensory Input

  • Lavrov et al., 2008 Facilitation of stepping with epidural stimulation in spinal rats: role of sensory input
  • Lavrov et al., 2015 Integrating multiple sensory systems to modulate neural networks controlling posture

Effect of Scaffold & SCS Therapy after Complete SCI

  • Siddiqui, Islam et al., 2021 Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation


Modulation of Spinally Evoked Motor Potentials

  • Lavrov et al., 2006 Plasticity of spinal cord reflexes after a complete transection in adult rats: relationship to stepping ability
  • Gerasimenko et al., 2006 Spinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats
  • Lavrov et al., 2008 Epidural stimulation induced modulation of spinal locomotor networks in adult spinal rats
  • Gad et al., 2013 Neuromodulation of motor-evoked potentials during stepping in spinal rats
  • Islam et al., 2019 Multifactorial motor behavior assessment for real-time evaluation of emerging therapeutics to treat neurologic impairments

Organization of Spinal Circuitry Mediating the Effects of SCS


Spinal Cord Vascular Organization in Effect of SCS

  • Song et al., 2019 Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study
  • Tang et al., 2020 Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation

Functional Imaging During EES

  • Laakso et al., 2021 Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats
  • Canna et al., 2021 Brain fMRI during orientation selective epidural spinal cord stimulation

Therapeutic Approaches for Acute SCI

  • Baltin et al., 2021 Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury
  • Kamalov et al., 2016 Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide
  • Baltin et al., 2016 Effects methylprednisolone, motor training and a combination in change parameters of M-response in the gastrocnemius muscle in rats during acute and chronic period after experimental spinal cord injury