LÅBORATORY

Lab Bench: Neuromodulation

Over last decades neuromodulation applications went beyond expectations and demonstrated that it can promote voluntary movement after complete spinal cord injury. To further enhance this approach, we are studying the effects noninvasive and invasive stimulation on multiple pre-clinical models and extending the clinical research to inform sensitive neurophysiological assessment in selection of responsive to neuromodulation subjects and improve optimization of neurostimulation protocols. With the goal to cover the key principles of neuromodulation and neuronal repair, this research efforts leading to the development of novel paradigms for prevention and treatment of spinal cord injury, neuropathic pain, for movement disorders, and other neurological conditions. 

Table of Contents:
  1. Lab Bench: Neuromodulation

Initiation and Maintenance of the Rhythmic Activity

  • Lavrov & Cheng, 2004 Activation of NMDA receptors is required for the initiation and maintenance of walking-like activity in the mudpuppy.
  • Lavrov & Cheng, 2008 Methodological optimization of applying neuroactive agents for the study of locomotor-like activity in the mudpuppies.
  • Lavrov et al., 2016 Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy

Activation of Locomotion with Epidural and Intraspinal Stimulation

  • Gerasimneko et al., 2001 Initiation of locomotor activity in spinalized cats by epidural stimulation of the spinal cord
  • Lavrov et al., 2015 Activation of spinal locomotor circuits in the decerebrated cat by spinal epidural and/or intraspinal electrical stimulation
  • Shah & Lavrov, 2017 Spinal Epidural Stimulation Strategies: Clinical Implications of Locomotor Studies in Spinal Rats

Non-invasive and Invasive Spinal Cord Stimulation for Restoration of Motor Control, Posture, and Balance

  • Militskova, 2020 Supraspinal and Afferent Signaling Facilitate Spinal Sensorimotor Network Excitability After Discomplete Spinal Cord Injury: A Case Report

Restoration of Volitional Motor Control after Spinal Cord Injury

  • Grahn et al., 2017 Enabling Task-Specific Volitional Motor Functions via Spinal Cord Neuromodulation in a Human With Paraplegia
  • Gill et al., 2018 Neuromodulation of lumbosacral spinal networks enables independent stepping after complete paraplegia
  • Calvert et al., 2019 Electrophysiological Guidance of Epidural Electrode Array Implantation over the Human Lumbosacral Spinal Cord to Enable Motor Function after Chronic Paralysis

Secondary Conditions after SCI

  • Beck et al., 2020 Impact of long-term epidural electrical stimulation enabled task-specific training on secondary conditions of chronic paraplegia in two humans
  • Beck et al., 2021 Potential impact of epidural stimulation on neurogenic bladder function and the value of urodynamic studies throughout usage

Home-based Neurorehabilitation

Basics of Neurorehabilitation

Facilitation of the Sensory Input

  • Lavrov et al., 2008 Facilitation of stepping with epidural stimulation in spinal rats: role of sensory input
  • Lavrov et al., 2015 Integrating multiple sensory systems to modulate neural networks controlling posture

Restoration and Control of Respiratory Functions with Neuromodulation

Control of Neuropathic Pain with Neuromodulation

  • Krushelnytskyy et al., 2019 Chronic subdural cortical stimulation for phantom limb pain: report of a series of two cases
  • Lavrov et al., 2019 Motor cortex stimulation for treatment of neuropathic pain: the role of pain assessment and trial-stimulation
  • Lavrov et al., 2021 Pre-motor vs. motor cerebral cortex neuromodulation for chronic neuropathic pain

Modulation of Translesional Spinal Network

  • Krupa et al., 2020 The Translesional Spinal Network and Its Reorganization after Spinal Cord Injury
  • Fadeev et al. 2020 Combined Supra- and Sub-Lesional Epidural Electrical Stimulation for Restoration of the Motor Functions after Spinal Cord Injury in Mini Pigs

Cell-mediated Gene Therapy and Spinal Cord Stimulation in Small and Large Animal Models of Incomplete SCI

  • Islamov et al. 2020 Epidural Stimulation Combined with Triple Gene Therapy for Spinal Cord Injury Treatment
  • Mukhamedshina et al. 2019 Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models
  • Islamov et al. 2017 A pilot study of cell-mediated gene therapy for spinal cord injury in mini pigs
  • Islamov et al. 2017 Evaluation of direct and cell-mediated triple-gene therapy in spinal cord injury in rats
  • Izmailov et al. 2017 Spinal Cord Molecular and Cellular Changes Induced by Adenoviral Vector- and Cell-Mediated Triple Gene Therapy after Severe Contusion

Scaffold and Spinal Cord Epidural Stimulation after Complete SCI

  • Siddiqui, Islam et al., 2021 Newly regenerated axons via scaffolds promote sub-lesional reorganization and motor recovery with epidural electrical stimulation

Modulation of Spinal Cord Motor Evoked Potentials

  • Lavrov et al., 2006 Plasticity of spinal cord reflexes after a complete transection in adult rats: relationship to stepping ability
  • Gerasimenko et al., 2006 Spinal cord reflexes induced by epidural spinal cord stimulation in normal awake rats
  • Lavrov et al., 2008 Epidural stimulation induced modulation of spinal locomotor networks in adult spinal rats
  • Gad et al., 2013 Neuromodulation of motor-evoked potentials during stepping in spinal rats
  • Islam et al., 2019 Multifactorial motor behavior assessment for real-time evaluation of emerging therapeutics to treat neurologic impairments

The Role of Spinal Cord Neuroanatomy in Effect of Spinal Cord Stimulation

  • Cuellar et al., 2017 The Role of Functional Neuroanatomy of the Lumbar Spinal Cord in Effect of Epidural Stimulation
  • Mendez et al., 2020 Segment-specific orientation of the dorsal and ventral roots for precise therapeutic targeting of human spinal cord

The Role of Spinal Cord Vascular Organization in Effect of Spinal Cord Stimulation

  • Song et al., 2019 Functional Ultrasound Imaging of Spinal Cord Hemodynamic Responses to Epidural Electrical Stimulation: A Feasibility Study
  • Tang et al., 2020 Changes in spinal cord hemodynamics reflect modulation of spinal network with different parameters of epidural stimulation

Functional Imaging During Electrical Epidural Stimulation

  • Laakso et al., 2021 Spinal cord fMRI with MB-SWIFT for assessing epidural spinal cord stimulation in rats
  • Canna et al., 2021 Brain fMRI during orientation selective epidural spinal cord stimulation

Therapeutic Approaches for Acute Spinal Cord Injury

  • Baltin et al., 2021 Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury
  • Kamalov et al., 2016 Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide
  • Baltin et al., 2016 Effects methylprednisolone, motor training and a combination in change parameters of M-response in the gastrocnemius muscle in rats during acute and chronic period after experimental spinal cord injury

Organization of Spinal Circuitry Responsible for the Effect of Electrical Epidural Stimulation

Spinal Cord Stimulation for Neuroprosthetics

  • Mikhaylov et al., 2020 Neurohybrid Memristive CMOS-Integrated Systems for Biosensors and Neuroprosthetics
  • Shah & Lavrov, 2017 Spinal Epidural Stimulation Strategies: Clinical Implications of Locomotor Studies in Spinal Rats
  • Gad et al., 2012 Forelimb EMG-based trigger to control an electronic spinal bridge to enable hindlimb stepping after a complete spinal cord lesion in rats
  • Nandra et al., 2011 Parylene-based microelectrode array implant for spinal cord stimulation in rats
  • Rodger et al., 2007 High-Density Flexible Parylene-Based Multielectrode Arrays for Retinal and Spinal Cord Stimulation